Cost Of Cialis Tablets

 

 

 

 

Cost Of Cialis Tablets

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Facial oedema 2. Sudden cardiac death 1,2

(1) Most of the patients had pre-existing cardiovascular risk factors (see section 4.4).

(2) Postmarketing surveillance reported adverse reactions not observed in placebo-controlled clinical trials.

(3) More commonly reported when tadalafil is given to patients who are already taking antihypertensive medicinal products.

Description of selected adverse reactions

A slightly higher incidence of ECG abnormalities, primarily sinus bradycardia, has been reported in patients treated with tadalafil once a day as compared with placebo. Most of these ECG abnormalities were not associated with adverse reactions.

Other special populations

Data in patients over 65 years of age receiving tadalafil in clinical trials, either for the treatment of erectile dysfunction or the treatment of benign prostatic hyperplasia, are limited. In clinical trials with tadalafil taken on demand for the treatment of erectile dysfunction, diarrhoea was reported more frequently in patients over 65 years of age. In clinical trials with tadalafil 5 mg taken once a day for the treatment of benign prostatic hyperplasia, dizziness and diarrhoea were reported more frequently in patients over 75 years of age.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via Ireland. HPRA Pharmacovigilance, Earlsfort Terrace, IRL – Dublin 2, Tel: +353 1 6764971, Fax: +353 1 6762517, Website: www.hpra.ie, e-mail: medsafety@hpra.ie, United Kingdom. Yellow Card Scheme, Website: www.mhra.gov.uk/yellowcard.

Single doses of up to 500 mg have been given to healthy subjects, and multiple daily doses up to 100 mg have been given to patients. Adverse events were similar to those seen at lower doses.

In cases of overdose, standard supportive measures should be adopted, as required. Haemodialysis contributes negligibly to tadalafil elimination.

5. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Urologicals, Drugs used in erectile dysfunction. ATC code: G04BE08.

Mechanism of action

Tadalafil is a selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5). When sexual stimulation causes the local release of nitric oxide, inhibition of PDE5 by tadalafil produces increased levels of cGMP in the corpus cavernosum. This results in smooth muscle relaxation and inflow of blood into the penile tissues, thereby producing an erection. Tadalafil has no effect in the treatment of erectile dysfunction in the absence of sexual stimulation.

Tadalafil 5 mg – The effect of PDE5 inhibition on cGMP concentration in the corpus cavernosum is also observed in the smooth muscle of the prostate, the bladder and their vascular supply. The resulting vascular relaxation increases blood perfusion which may be the mechanism by which symptoms of benign prostatic hyperplasia are reduced. These vascular effects may be complemented by inhibition of bladder afferent nerve activity and smooth muscle relaxation of the prostate and bladder.

Studies in vitro have shown that tadalafil is a selective inhibitor of PDE5. PDE5 is an enzyme found in corpus cavernosum smooth muscle, vascular and visceral smooth muscle, skeletal muscle, platelets, kidney, lung, and cerebellum. The effect of tadalafil is more potent on PDE5 than on other phosphodiesterases. Tadalafil is >10,000-fold more potent for PDE5 than for PDE1, PDE2, and PDE4 enzymes which are found in the heart, brain, blood vessels, liver, and other organs. Tadalafil is >10,000-fold more potent for PDE5 than for PDE3, an enzyme found in the heart and blood vessels. This selectivity for PDE5 over PDE3 is important because PDE3 is an enzyme involved in cardiac contractility. Additionally, tadalafil is approximately 700-fold more potent for PDE5 than for PDE6, an enzyme which is found in the retina and is responsible for phototransduction. Tadalafil is also >10,000-fold more potent for PDE5 than for PDE7 through PDE10.

Clinical efficacy and safety

Tadalafil administered to healthy subjects produced no significant difference compared to placebo in supine systolic and diastolic blood pressure (mean maximal decrease of 1.6/0.8mmHg, respectively), in standing systolic and diastolic blood pressure (mean maximal decrease of 0.2/4.6mmHg, respectively), and no significant change in heart rate.

In a study to assess the effects of tadalafil on vision, no impairment of colour discrimination (blue/green) was detected using the Farnsworth-Munsell 100-hue test. This finding is consistent with the low affinity of tadalafil for PDE6 compared to PDE5. Across all clinical studies, reports of changes in colour vision were rare (<0.1%).

Three studies were conducted in men to assess the potential effect on spermatogenesis of CIALIS 10mg (one 6-month study) and 20mg (one 6-month and one 9-month study) administered daily. In two of these studies decreases were observed in sperm count and concentration related to tadalafil treatment of unlikely clinical relevance. These effects were not associated with changes in other parameters, such as motility, morphology, and FSH.

Three clinical studies were conducted in 1054 patients in an at-home setting to define the period of responsiveness to CIALIS on demand. Tadalafil demonstrated statistically significant improvement in erectile function and the ability to have successful sexual intercourse up to 36 hours following dosing, as well as patients’ ability to attain and maintain erections for successful intercourse compared to placebo as early as 16 minutes following dosing.

In a 12-week study performed in 186 patients (142 tadalafil, 44 placebo) with erectile dysfunction secondary to spinal cord injury, tadalafil significantly improved the erectile function leading to a mean per-subject proportion of successful attempts in patients treated with tadalafil 10 or 20 mg (flexible-dose, on demand) of 48% as compared to 17% with placebo.

Tadalafil at doses of 2 to 100mg has been evaluated in 16 clinical studies involving 3250 patients, including patients with erectile dysfunction of various severities (mild, moderate, severe), etiologies, ages (range 21-86 years), and ethnicities. Most patients reported erectile dysfunction of at least 1 year in duration. In the primary efficacy studies of general populations, 81% of patients reported that CIALIS improved their erections as compared to 35% with placebo. Also, patients with erectile dysfunction in all severity categories reported improved erections whilst taking CIALIS (86%, 83%, and 72% for mild, moderate, and severe, respectively, as compared to 45%, 42%, and 19% with placebo). In the primary efficacy studies, 75% of intercourse attempts were successful in CIALIS-treated patients as compared to 32% with placebo.

For once-a-day evaluation of tadalafil at doses of 2.5, 5, and 10 mg 3 clinical studies were initially conducted involving 853 patients of various ages (range 21-82 years) and ethnicities, with erectile dysfunction of various severities (mild, moderate, severe) and etiologies. In the two primary efficacy studies of general populations, the mean per-subject proportion of successful intercourse attempts were 57 and 67% on CIALIS 5mg, 50% on CIALIS 2.5mg as compared to 31 and 37% with placebo. In the study in patients with erectile dysfunction secondary to diabetes, the mean per-subject proportion of successful attempts were 41 and 46% on CIALIS 5mg and 2.5mg, respectively, as compared to 28% with placebo. Most patients in these three studies were responders to previous on-demand treatment with PDE5 inhibitors. In a subsequent study, 217 patients who were treatment-naive to PDE5 inhibitors were randomised to CIALIS 5mg once a day vs. placebo. The mean per-subject proportion of successful sexual intercourse attempts was 68% for CIALIS patients compared to 52% for patients on placebo.

Benign prostatic hyperplasia

CIALIS was studied in 4 clinical studies of 12 weeks duration enrolling over 1500 patients with signs and symptoms of benign prostatic hyperplasia. The improvement in the total international prostate symptom score with CIALIS 5mg in the four studies were -4.8, -5.6, -6.1 and -6.3 compared to -2.2, -3.6, -3.8 and -4.2 with placebo. The improvements in total international prostate symptom score occurred as early as 1 week. In one of the studies, which also included tamsulosin 0.4 mg as an active comparator, the improvement in total international prostate symptom score with CIALIS 5mg, tamsulosin and placebo were -6.3, -5.7 and -4.2 respectively.

One of these studies assessed improvements in erectile dysfunction and signs and symptoms of benign prostatic hyperplasia in patients with both conditions. The improvements in the erectile function domain of the international index of erectile function and the total international prostate symptom score in this study were 6.5 and -6.1 with CIALIS 5 mg compared to 1.8 and -3.8 with placebo, respectively. The mean per-subject proportion of successful sexual intercourse attempts was 71.9% with CIALIS 5 mg compared to 48.3% with placebo.

The maintenance of the effect was evaluated in an open-label extension to one of the studies, which showed that the improvement in total international prostate symptom score seen at 12 weeks was maintained for up to 1 additional year of treatment with CIALIS 5mg.

The European Medicines Agency has waived the obligation to submit the results of studies in all subsets of the paediatric population in the treatment of the erectile dysfunction. See section 4.2 for information on paediatric use.

5.2 Pharmacokinetic properties

Tadalafil is readily absorbed after oral administration and the mean maximum observed plasma concentration (Cmax ) is achieved at a median time of 2 hours after dosing. Absolute bioavailability of tadalafil following oral dosing has not been determined.

The rate and extent of absorption of tadalafil are not influenced by food, thus CIALIS may be taken with or without food. The time of dosing (morning versus evening) had no clinically relevant effects on the rate and extent of absorption.

The mean volume of distribution is approximately 63 l, indicating that tadalafil is distributed into tissues. At therapeutic concentrations, 94% of tadalafil in plasma is bound to proteins. Protein binding is not affected by impaired renal function.

Less than 0.0005% of the administered dose appeared in the semen of healthy subjects.

Tadalafil is predominantly metabolised by the cytochrome P450 (CYP) 3A4 isoform. The major circulating metabolite is the methylcatechol glucuronide. This metabolite is at least 13,000-fold less potent than tadalafil for PDE5. Consequently, it is not expected to be clinically active at observed metabolite concentrations.

The mean oral clearance for tadalafil is 2.5 l/h and the mean half-life is 17.5 hours in healthy subjects.

Tadalafil is excreted predominantly as inactive metabolites, mainly in the faeces (approximately 61% of the dose) and to a lesser extent in the urine (approximately 36% of the dose).

Tadalafil pharmacokinetics in healthy subjects are linear with respect to time and dose. Over a dose range of 2.5 to 20 mg, exposure (AUC) increases proportionally with dose. Steady-state plasma concentrations are attained within 5 days of once daily dosing.

Pharmacokinetics determined with a population approach in patients with erectile dysfunction are similar to pharmacokinetics in subjects without erectile dysfunction.

Healthy elderly subjects (65 years or over) had a lower oral clearance of tadalafil, resulting in 25% higher exposure (AUC) relative to healthy subjects aged 19 to 45 years. This effect of age is not clinically significant and does not warrant a dose adjustment.

In clinical pharmacology studies using single dose tadalafil (5 to 20mg), tadalafil exposure (AUC) approximately doubled in subjects with mild (creatinine clearance 51 to 80 ml/min) or moderate (creatinine clearance 31 to 50 ml/min) renal impairment and in subjects with end-stage renal disease on dialysis. In haemodialysis patients, Cmax was 41% higher than that observed in healthy subjects. Haemodialysis contributes negligibly to tadalafil elimination.

Tadalafil exposure (AUC) in subjects with mild and moderate hepatic impairment (Child-Pugh class A and B) is comparable to exposure in healthy subjects when a dose of 10 mg is administered. There is limited clinical data on the safety of CIALIS in patients with severe hepatic insufficiency (Child-Pugh class C). If CIALIS is prescribed, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. There are no available data about the administration of once-a-day dosing of tadalafil to patients with hepatic impairment. If CIALIS is prescribed once-a-day, a careful individual benefit/risk evaluation should be undertaken by the prescribing physician. There are no available data about the administration of doses higher than 10 mg of tadalafil to patients with hepatic impairment.

Patients with Diabetes

Tadalafil exposure (AUC) in patients with diabetes was approximately 19% lower than the AUC value for healthy subjects. This difference in exposure does not warrant a dose adjustment.

5.3 Preclinical safety data

Non-clinical data reveal no special hazard for humans based on conventional studies of safety pharmacology, repeated dose toxicity, genotoxicity, carcinogenic potential, and toxicity to reproduction.

There was no evidence of teratogenicity, embryotoxicity, or foetotoxicity in rats or mice that received up to 1000 mg/kg/day tadalafil. In a rat prenatal and postnatal development study, the no observed effect dose was 30 mg/kg/day. In the pregnant rat the AUC for calculated free drug at this dose was approximately 18-times the human AUC at a 20 mg dose.

There was no impairment of fertility in male and female rats. In dogs given tadalafil daily for 6 to 12 months at doses of 25 mg/kg/day (resulting in at least a 3-fold greater exposure [range 3.7-18.6] than seen in humans given a single 20 mg dose) and above, there was regression of the seminiferous tubular epithelium that resulted in a decrease in spermatogenesis in some dogs. See also section 5.1.

6. Pharmaceutical particulars

6.1 List of excipients

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Where Are The Best Places to Buy Cialis Online?

Just like Viagra, people always ask me “Where is the best place to buy Cialis online?” Before writing this page, we investigated the top websites that sell Cialis online. We keep this information up-to-date, so all shoppers should find the Cialis costs to be current. After doing research we found out that convenience, privacy, and Authentic Medications are the reason shoppers chose some websites over others.

Who Does CoreyNahman.com Recommend?

Stay away from the bootlegs. If you are looking for genuine, brand-name Cialis Online manufactured by Eli Lilly, I recommend AccessRx.com. They have been in business since 1998. They are located in the USA in Tempe Arizona. They offer overnight shipping, and they keep their Cialis cost reasonable.

They have a 24 hour telephone number for customer service. They even have licensed physicians and pharmacists on staff to answer your medical questions.

Their prices are higher than the generics but you are assured of getting brand-name, American, FDA-Approved Cialis (and other medications) delivered to your door in a couple of days without having to go to a doctor and provide a co-pay.

If you plan to buy Cialis online, definitely check out AccessRx before you make a decision.

Who is Buying Cialis Online

More and more people are choosing to buy Cialis online. In 2003 worldwide Cialis sales were $203.3 million. According to Eli Lilly, in 2008 worldwide Cialis sales jumped to $1.44 billion. a 700% increase since it was launched in the United States!

Cialis’ popularity is catching up to Viagra (which sold $1.934 billion worldwide in 2008). This is the first time Cialis is within $500 million in sales to Viagra worldwide. In 2008 daily Cialis was launched. which should boost Cialis sales even further towards reaching Viagra.

Since so many people are buying Cialis, it is a tempting pill for unscrupulous online merchants to bootleg or make counterfeit copies of, with the eye on making a quick dollar.

Q: Is there a generic Cialis?
A: No

There is no such thing as an FDA approved generic Cialis. The Cialis patent is good until at least 2015 (source = Eli Lilly 2009 annual report, p 50). This means that Lilly has a legal monopoly on all versions of Cialis.

If you see a website advertising generic Cialis for sale, that means it is an unapproved, unauthorized bootleg version or an outright counterfeit pill. As mentioned earlier, the cost of Cialis that is authentic and approved by the FDA is more than illegal “generic” Cialis.

Q: What if I tried generic Cialis and it worked?
A: If you buy “generic” Cialis online, it may work. BUT.

you have no way of telling for sure what the active ingredient is or how much is present. You might be paying for a 20 mg dose but only getting 7mg or 8mg. Or you might be getting a dangerously high dose without knowing it.

The tablets may contain tadalafil (the active ingredient in Cialis) but they may contain something like silendafil (the active ingredient in Viagra or vardenafil the active ingredient in Levitra). It’s a crapshoot.

The only way to tell for sure would be for you to send the pills out to a pharmaceutical laboratory for a chemical analysis, but unless you are a scientist or a CSI expert this is not a realistic option. When you buy Cialis online that is sold as “generic,” you become your own guinea pig and you hope for the best. Although the your Cialis cost will be higher for the authentic version, you will have peace of mind knowing that the medication is safe and effective.

Q: If it’s not legitimate, why do they sell it?
A: The number of people sell fake Cialis online, outnumber the agencies that regulate this type of thing and the government can’t keep up.

The government considers generic Cialis to be an illegal substance. They are concerned about public health and safety issues, particularly since many non-regulated internet pharmacies sell you pharmaceuticals without a doctor’s prescription.

They don’t go after the people who buy generic Cialis online but postal authorities will interdict it at the border whenever possible. Every once in a while they go after the major players and shut down their operations.

The sellers are usually charged with mail fraud and or conspiracy to introduce misbranded drugs into interstate commerce in violation of the Federal Food, Drug, and Cosmetic Act .

Q: Where is the best place to buy Cialis Online?
A: There is no one best place to buy Cialis online but there are red flags for spotting scam Cialis sellers:

– The Cialis price should be realistic. You get what you pay for. Genuine, FDA approved Cialis should cost at least $38 per pill. If you are seeing offers for $3.00 or $4.00 per dose it is a guarantee that you are not getting the real thing.

– Google the operation that is selling the Cialis online. Do a little detective work. If they are selling shady products, or they have ripped people off in the past there is a good chance that someone has complained about them on a message board or in a blog. Google their phone number, their address, the name of the website, etc. You would be surprised to see what turns up.

– Lots of pharmacies selling Cialis online pretend to be American or Canadian but are actually located in developing nations, particularly India, Mexico and the Caribbean Basin. You want to screen out these non-North American operations.

The online pharmacy should have a physical address (not a just P.O. box) in the Unites Stated or Canada and a working telephone number. Call the number and test it out. Speak with a customer service representative. Ask a few questions such as, “what is your shipping policy? What is your return policy? What is the name of your supervising pharmacist? What is your pharmacy license number”. They should answer your questions courteously in perfect English. If they sound fishy on the phone stay away.

– Their ad should purport to sell “genuine Cialis”, “FDA approved Cialis” or “Brand Name Cialis”.

– If the ad says generic Cialis, chewable Cialis, Cialis strips, liquid or gelcaps this is a big red flag since as we have discussed above there is no such thing as generic Cialis. Generic Cialis or Cialis in any formulation other than tablets mean bootlegged product or a product that contains no active ingredient.

– A prescription should be required. If they are a reputable outfit, You should be required to do one of the following:
(A) Have one of their doctors examine you via a questionnaire or an online examination.
(B) Mail or fax them a prescription.
(C) Have them call your doctor to get a telephone prescription.

If the ad says. "No Prescription Needed", that’s a bad sign. That means that you are probably dealing with an offshore internet pharmacy that sells anything to anyone. Just because a person has a website and a computer does not mean they should be trusted to sell Cialis online. Use good judgment when you buy Cialis online.

Who this site recommends & why we recommend them:

If you are looking for the authentic Brand Name Cialis, I recommend AccessRx.com. They do not sell generic Cialis, which is good considering that it is illegal and dangerous to your health. AccessRx.com has been serving customers conveniently and safely since 1998. They are located in the USA in Tempe Arizona. Their customer service representatives are available 6-days a week and they have licensed physicians and pharmacists on staff to answer your medical questions.

AccessRx.com does have higher prices than generics but you are 100% assured that you will be getting the brand-name American, FDA-Approved Cialis delivered to your door conveniently in a couple of days without having to visit your own doctor.

1/10/08: A New Way To Take Cialis; Every Single Day!

Beginning in January of 2008, Lilly began marketing Cialis in a different manner. Cialis became approved for every day low-dose administration as an option for men with erectile dysfunction who engage in sex frequently (more than twice per week) so that men can engage in sex any time between doses rather than waiting for a pill to kick in.

Cialis for every-day-administration is given in a lower dose – 2.5mg to start (as opposed to the 10mg or 20mg that occasional users take). If the 2.5mg per day is inadequate, the dose can be doubled to 5mg per day. Your Cialis cost for a week’s worth of low dose therapy is comparable for what a man would pay if he takes two tablets per week. The cost of Cialis, unfortunately, has increased to more than $25 per pill, but that’s still better than risking your health by taking illegal “generic” Cialis.

Cialis is available 2.5mg, 5mg, 10mg and 20mg tablets.

If you are going to take Cialis the traditional way, every once in a while in anticipation of having sex, the recommended dose is 10mg taken prior to anticipated sexual activity without regard to food. In those patients in whom 10mg does not produce an adequate effect, 20mg might be tried.

It can be taken from 30 minutes to 12 hours prior to sexual activity. The efficacy of tadalafil may persist up to 24 hours post-dose. The maximum recommended dose of the 10mg or 20mg tablets is one pill per day.

How Does Cialis Work?

When an erection goes limp, you have PDE5 to thank.
Specialized penis tissue produces a substance called cyclic guanosine monophosphate (cGMP) in response to sexual stimulation. The more cGMP available, the more Durable the erection. Cialis inhibits the PDE5 enzyme, preserving cGMP levels, therefore aiding erection viability and durability.

Cialis is a member of a family of drugs known as PDE5 enzyme inhibitors.

Cialis is known as the “36 hour pill” or the “weekend pill” because unlike other similar drugs, Cialis has a long duration of action.

Cialis blocks an enzyme that causes an erection to go flaccid. Although Cialis is similar to Levitra and Viagra, its dose, onset of action, and duration of action is unique.

Cialis is a member of a family of drugs called PDE5 Inhibitors. Cialis is now marketed in approximately 40 countries and is available by prescription in pharmacies on five continents.

Cialis was developed by Icos, a small biotech company located in Washington State. Icos formed a 50/50 joint venture with Eli Lilly & company. Eventually, Lilly bought out Icos.

The BIG Discovery: cyclic guanosine monophosphate (cGMP)

When a man gets sexually stimulated, a chain reaction occurs in the tissue of the penis that results in elevated levels of a substance called cyclic guanosine monophosphate (cGMP).

As long as there are sufficient levels of cGMP, the penis can remain erect. The more cGMP, the more robust and durable the erection.

If you inhibit the degradation of cGMP it stays around in the penis longer, producing a more durable erection.

Cialis is that it preserves the elevated levels of cGMP that are created when a man is sexually stimulated for a stronger, more durable erection.

Cialis blocks the enzyme phosphodiesterase-5 (PDE5) which is responsible for the neutralization of cGMP. Cialis (tadalafil) is a highly selective inhibitor of PDE5. (PDE5 is not the only phosphodiesterase involved in the erectile physiology but it appears to be the most important one).

The nice thing about Cialis is that it won’t cause erections at inappropriate times because it only blocks degradation of cGMP produced in reaction to sexual stimulation, such as thinking about something sexy. If you are not being sexually stimulated, there is no cGMP to protect, so the drug remains in the background.

How Does Cialis Compare To Viagra and Levitra?

One huge difference is that Cialis is used to tread erectile dysfunction as though it is a chronic condition. As stated above, only Cialis is approved by the FDA to be taken once-per-day whether or not you are going to engage in sex. Viagra, on the other hand, is only taken just before sex. Here is a complete table that shows the difference between Viagra, Cialis, and Levitra.

Cialis Versus Viagra
Cialis Versus Viagra From Forbes magazine 12/03/03; M. Herper; side by side comparison of various characteristics of Cialis and Viagra in slide show format.

Cialis Versus Viagra Versus Levitra (2004 Media Report)
Viagra Faces Stiff Competition On Airwaves � Viagra focuses on depicting happy men in their ads. Levitra uses a woman’s testimonial and sports star Mike Ditka. Cialis, which is more subtle and longer-lasting, focuses on the relationship. [ WFTV.com]
Editor’s Note: Above report offers comparison between Cialis, Viagra and Levitra in terms of advertising.

Absorption, Onset, Bioavailability

Cialis is readily absorbed from the bloodstream. It is about 16% bioavailable. Tadalafil is about 94% bound to plasma protein. Maximum plasma concentration of Tadalafil was achieved 2 hours post dose. The Cialis label states that It can be taken from 30 minutes to 12 hours prior to sexual activity. Efficacy of tadalafil may persist up to 24 hours post-dose.

Metabolism, Half Life, Excretion

Cialis is mostly metabolized in the liver by an enzyme known as CYP3A4 and to a lesser extent CYPC2. Tadalafil breakdown products are excreted in the feces (61%) and in the urine (36%). Cialis’ mean half life is 17.5 hours in healthy men.

If you are going to take any of the PDE5 inhibitors such as Cialis, it is very important that your doctor be aware if you have a liver condition (such as cirrhosis) or kidney condition ( such as if you are on dialysis) because you may need a special dosage adjustment.

Likewise, if you try to buy Cialis online, please make sure that the person authorizing your prescription knows the true status of your liver function and your kidney function.

Non-Sexual Uses Of Cialis (tadalafil):

Benign Prostate Enlargement:
Recent information published in scientific journals indicate that Cialis may be useful for treating lower urinary tract symptoms associated with benign enlargement of the prostate. Of the doses studied, the 5 mg Cialis dose seemed to be the most appropriate dose.
See Also: J Urol. 2008 Aug 21. (abstract). CONCLUSIONS: Once daily tadalafil demonstrated clinically meaningful and statistically significant efficacy and it was well tolerated in men with benign prostatic hyperplasia lower urinary tract symptoms.
See Also: Impotence Drug Eases Prostate Problems. new research, funded by Eli Lilly, the company that owns the rights to the drug tadalafil, shows a daily dose of the drug may help ease some of the urinary symptoms related to an enlarged prostate. [WebMD]

Altitude Sickness
Because of Cialis’ effect on the cardiovascular system, researchers are looking into if it is beneficial to administer Cialis it to people who are susceptible to high altitude sickness. Early data indicates it has a moderate beneficial effect:
See Also: Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1651-7. Epub 2008 Feb 29. Evidence supportive of impaired myocardial blood flow reserve at high altitude in subjects developing high-altitude pulmonary edema.
See Also: Ann Intern Med. 2006 Oct 3;145(7):497-506. Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial �[ Annals of Internal Medicine; Abstract]
See Also: Stroke. 2005 Mar;36(3):557-60. Epub 2005 Feb 3. Effects of high altitude exposure on cerebral hemodynamics in normal subjects �[Stroke; Abstract]

Cialis Price Check. 10 top sites that sell Cialis; simple comparison shopping.

Cialis.com. Brand new website; prescribing information, patient information, safety information, FAQ, etc.

Cialis Prescribing Information. Dose, mechanism of action, side effects, precautions, warnings; patient information; very technical, don’t get scared when you come to the section on warnings and side effects. [ This is the information that doctors will use when they are considering prescribing Cialis]

Cialis Side Effects & Drug Interactions. 2,800 word report regarding side effects and drug interactions taken from Cialis’ official FDA label; includes seven charts and graphs.

Cialis Recall Information – up to date information regarding possible Cialis recalls if appropriate.*
* There has never been a Cialis recall so this page should be blank.

FDA Cialis Page. Cialis talk paper, Cialis label, Cialis approval letter, Questions and answers for Cialis, Cialis consumer drug information sheet.

Cialis Talk Paper [FDA]. from FDA’s official website; explains how Cialis is different from other erectile dysfunction drugs, starting dose, metabolism, possible drug interactions, contraindications.

Cialis Questions & Answers [FDA]. what is Cialis used for, how does it work, how is it different from similar drugs, how do you take cialis, common doses, etc. Similar to the drugtore flyer you get when you pick up a prescription at the drugstore.

Cialis Scientific Papers (from the National Library of medicine) automated Medline search; a listing of scientific papers in abstract form regarding Cialis.

Cialis News (from Google) recently published news regarding Cialis.

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You are here: Home > Cialis Price

Cialis Price

There are several oral medications that are prescribed to treat impotence in most men and one of those is Cialis. To be more specific, Cialis is utilized in order to treat reduced sexual performance that is caused by erectile dysfunction. For any form of medication, in order for it to become efficient, it needs to be taken in the accurate dosage and this holds true for Cialis as well. Knowing the accurate dosage of such medicine is the primary key to solving your erectileproblems.

Cialis is not only prescribed to treat men’s ED (Erectile Dysfunction), but also to treat those men with the symptoms and signs of BPH (Benign Prostatic Hyperplasia) as well as those men who have both these BPH signs and symptoms of ED. This medicine is not to be used by children or women. Cialis is the brand name of Tadalafil, which is known as PDE5 inhibitor. The chemical formula of this drug is C22 H19 N3 O4. Cialis is also made popular by the nickname “The Weekend Pill”, as its effects may last up to 36 hours. A PDE5 (PhosphoDiesterase Type 5) inhibitor is the type of medication that is applied to hinder the cGMP’s (cyclic GMP) degradative action within the even muscle cells, which keeps blood vessels in line to supply blood to the the corpus cavernosa (2 tubes which run along the penis). This inhibitor is also found within the soft muscle of arteries’ walls inside the lungs. Hence, it has been discovered effective for treating pulmonary hypertension, as well.

Cialis Cost Information

The prices of Cialis may vary depending on the quantity, dosage, insurance and even the pharmacy that sells this product. These prices are based without insurance and if have insurance, then you should call the particular pharmacy to verify the exact price.

Short-Term Side Effects

Even though a daily intake of Cialis with 2.5mg dosage is measured to be safe, the usage of Cialis for a long period is not recommended. Short term application of Cialis can prevent many severe side effects, and most significantly, it can avoid damage to one’s penis. A person must not become too dependent on Cialis to achieve favorable erection.

Long-Term Side Effects

Taking Cialis, along with other medications containing nitrate, may cause a sudden and serious hypotension or drop in blood pressure. So, make sure not to take the medicine if you are under the prescription of a nitrate drug for chest pain or heart problems. If you are on sexual intercourse and you feel nauseated or dizzy, or if you are experiencing tingling, numbness or some sort of pain in your neck, chest, jaw or arms, consider discontinuing and immediately contact your doctor. Experiencing these symptoms may be one of the serious side effects of Cialis, although those are rare.

Interactions

Tell your doctor about other medicines you are taking particularly the following, as they may cause some interactions with Cialis:

  • Nitrates medicines, usually chest pain prescriptions
  • Medications for blood pressure
  • HIV medications or other forms of antifungal oral medications
  • Some forms of antibiotics including telithromycin, clarithromycin, and erythromycin.
  • Other treatments or medicines for ED (Erectile Dysfunction)
  • Cialis is also sold as Adcirca for treating pulmonary arterial hypertension, so make sure not to take both Adcirca and Cialis.

How It Works

Cialis is a medication which has been certified to treat erectile dysfunction, which is a chronic inability to keep erection process firm enough to sustain sexual intercourse. This medication functions through enabling the penis’ arteries to open wider in order to allow sufficient blood flow to the organ. This will eventually lead to an enhanced erection.

Generic Alternatives

If the Cialis price is too high for you, there is a generic called tadalafil, which is cheaper than Cialis.

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Cost Of Cialis Tablets

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